Essentials of Inorganic Chemistry by Katja A Strohfeldt

Essentials of Inorganic Chemistry by Katja Strohfeldt

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Contents of Essentials of Inorganic Chemistry

  • About the Companion Website
  • Introduction
  • Medicinal inorganic chemistry
  • Why use metal-based drugs?
  • Basic inorganic principles
  • Electronic structures of atoms
  • Bonds
  • Exercises
  • References
  • Further Reading
  • Alkali Metals
  • Alkali metal ions
  • Extraction of alkali metals: an introduction to redox chemistry
  • Excursus: reduction – oxidation reactions
  • Chemical behaviour of alkali metals
  • Advantages and disadvantages using lithium-based drugs
  • Isotopes of lithium and their medicinal application
  • Historical developments in lithium-based drugs
  • The biology of lithium and its medicinal application
  • Excursus: diagonal relationship and periodicity
  • What are the pharmacological targets of lithium?
  • Adverse effects and toxicity
  • Sodium: an essential ion in the human body
  • Osmosis
  • Active transport of sodium ions
  • Drugs, diet and toxicity
  • Potassium and its clinical application
  • Biological importance of potassium ions in the human body – action potential
  • Excursus: the Nernst equation
  • Potassium salts and their clinical application: hypokalaemia
  • Adverse effects and toxicity: hyperkalaemia
  • Exercises
  • Case studies
  • Lithium carbonate (Li CO ) tablets
  • Sodium chloride eye drops
  • References
  • Further Reading
  • Alkaline Earth Metals
  • Earth alkaline metal ions
  • Major uses and extraction
  • Chemical properties
  • Beryllium and chronic beryllium disease
  • Magnesium: competition to lithium?
  • Biological importance
  • Clinical applications and preparations
  • Calcium: the key to many human functions
  • Biological importance
  • How does dietary calcium intake influence our lives?
  • Calcium deficiency: osteoporosis, hypertension and weight management
  • Renal osteodystrophy
  • Kidney stones
  • Clinical application
  • Side effects
  • Barium: rat poison or radio-contrast agent?
  • Exercises
  • Case studies
  • Magnesium hydroxide suspension
  • Calcium carbonate tablets
  • References
  • Further Reading
  • The Boron Group – Group
  • General chemistry of group elements
  • Extraction
  • Chemical properties
  • Boron
  • Introduction
  • Pharmaceutical applications of boric acid
  • Bortezomib
  • Aluminium
  • Introduction
  • Biological importance
  • Al + and its use in water purification
  • Aluminium-based adjuvants
  • Antacids
  • Aluminium-based therapeutics – alginate raft formulations
  • Phosphate binders
  • Antiperspirant
  • Potential aluminium toxicity
  • Gallium
  • Introduction
  • Chemistry
  • Pharmacology of gallium-based drugs
  • Gallium nitrate – multivalent use
  • Gallium -quinolinolate
  • Gallium maltolate
  • Toxicity and administration
  • Exercises
  • Case studies
  • Boric acid – API analysis
  • Aluminium hydroxide tablets
  • References
  • Further Reading
  • The Carbon Group
  • General chemistry of group elements
  • Occurrence, extraction and use of group elements
  • Oxidation states and ionisation energies
  • Typical compounds of group elements
  • Silicon-based drugs versus carbon-based analogues
  • Introduction of silicon groups
  • Silicon isosters
  • Organosilicon drugs
  • Organogermanium compounds: balancing act between an anticancer drug and a herbal
  • supplement
  • Germanium sesquioxide
  • Spirogermanium
  • Exercises
  • Cases studies
  • Simethicone
  • Germanium supplements
  • References
  • Further Reading
  • Group Elements
  • Chemistry of group elements
  • Occurrence and extraction
  • Physical properties
  • Oxidation states and ionisation energy
  • Chemical properties
  • Phosphorus
  • Adenosine phosphates: ATP, ADP and AMP
  • Phosphate in DNA
  • Clinical use of phosphate
  • Drug interactions and toxicity
  • Arsenic
  • Salvarsan: the magic bullet – the start of chemotherapy
  • Arsenic trioxide: a modern anticancer drug?
  • Exercises
  • Case studies
  • Phosphate solution for rectal use
  • Forensic test for arsenic
  • References
  • Further Reading
  • Transition Metals and d-Block Metal Chemistry
  • What are d-block metals?
  • Electronic configurations
  • Characteristic properties
  • Coordination numbers and geometries
  • Crystal field theory
  • Group : platinum anticancer agents
  • Cisplatin
  • Platinum anticancer agents
  • Iron and ruthenium
  • Iron
  • Ruthenium
  • The coinage metals
  • General chemistry
  • Copper-containing drugs
  • Silver: the future of antimicrobial agents?
  • Gold: the fight against rheumatoid arthritis
  • Group elements: zinc and its role in biological systems
  • General chemistry
  • The role of zinc in biological systems
  • Zinc: clinical applications and toxicity
  • Exercises
  • Case studies
  • Silver nitrate solution
  • Ferrous sulfate tablets
  • Zinc sulfate eye drops
  • References
  • Further Reading
  • Organometallic Chemistry
  • What is organometallic chemistry?
  • What are metallocenes?
  • Ferrocene
  • Ferrocene and its derivatives as biosensors
  • Ferrocene derivatives as potential antimalarial agent
  • Ferrocifen – a new promising agent against breast cancer?
  • Titanocenes
  • History of titanium-based anticancer agents: titanocene dichloride and budotitane
  • Further developments of titanocenes as potential anticancer agents
  • Vanadocenes
  • Vanadocene dichloride as anticancer agents
  • Further vanadium-based drugs: insulin mimetics
  • Exercises
  • Case study – titanium dioxide
  • References
  • Further Reading
  • The Clinical Use of Lanthanoids
  • Biology and toxicology of lanthanoids
  • The clinical use of lanthanum carbonate
  • The clinical application of cerium salts
  • The use of gadolinium salts as MRI contrast agents
  • Exercises
  • Case study: lanthanum carbonate tablets
  • References
  • Further Reading
  • Radioactive Compounds and Their Clinical Application
  • What is radioactivity?
  • The atomic structure
  • Radioactive processes
  • Radioactive decay
  • Penetration potential
  • Quantification of radioactivity
  • Radiopharmacy: dispensing and protection
  • Therapeutic use of radiopharmaceuticals
  • Iodine: therapy for hyperthyroidism
  • Strontium
  • Boron neutron capture therapy (BNCT)
  • Radiopharmaceuticals for imaging
  • Technetium
  • Fluoride: PET scan
  • Gallium: PET
  • Thallium
  • Exercises
  • Case studies
  • A sample containing mTc was found to have a radioactivity of mCi at a m
  • when the sample was tested
  • A typical intravenous dose of mTc-albumin used for lung imaging contains a
  • radioactivity of mCi
  • Develop a quick-reference radioactive decay chart for I
  • References
  • Further Reading
  • Chelation Therapy
  • What is heavy-metal poisoning?
  • What is chelation?
  • Chelation therapy
  • Calcium disodium edetate
  • Dimercaprol (BAL)
  • Dimercaptosuccinic acid (DMSA)
  • Dimercapto- -propanesulfonic acid (DMPS)
  • Lipoic acid (ALA)
  • Exercises
  • Case studies
  • Disodium edetate
  • Dimercaprol
  • References
  • Further Reading
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