PDF Free Download | Essentials of Inorganic Chemistry by Katja A. Strohfeldt

Contents of Essentials of Inorganic Chemistry

• About the Companion Website
• Introduction
• Medicinal inorganic chemistry
• Why use metal-based drugs?
• Basic inorganic principles
• Electronic structures of atoms
• Bonds
• Exercises
• References
• Further Reading
• Alkali Metals
• Alkali metal ions
• Extraction of alkali metals: an introduction to redox chemistry
• Excursus: reduction – oxidation reactions
• Chemical behaviour of alkali metals
• Advantages and disadvantages using lithium-based drugs
• Isotopes of lithium and their medicinal application
• Historical developments in lithium-based drugs
• The biology of lithium and its medicinal application
• Excursus: diagonal relationship and periodicity
• What are the pharmacological targets of lithium?
• Adverse effects and toxicity
• Sodium: an essential ion in the human body
• Osmosis
• Active transport of sodium ions
• Drugs, diet and toxicity
• Potassium and its clinical application
• Biological importance of potassium ions in the human body – action potential
• Excursus: the Nernst equation
• Potassium salts and their clinical application: hypokalaemia
• Adverse effects and toxicity: hyperkalaemia
• Exercises
• Case studies
• Lithium carbonate (Li CO ) tablets
• Sodium chloride eye drops
• References
• Further Reading
• Alkaline Earth Metals
• Earth alkaline metal ions
• Major uses and extraction
• Chemical properties
• Beryllium and chronic beryllium disease
• Magnesium: competition to lithium?
• Biological importance
• Clinical applications and preparations
• Calcium: the key to many human functions
• Biological importance
• How does dietary calcium intake influence our lives?
• Calcium deficiency: osteoporosis, hypertension and weight management
• Renal osteodystrophy
• Kidney stones
• Clinical application
• Side effects
• Barium: rat poison or radio-contrast agent?
• Exercises
• Case studies
• Magnesium hydroxide suspension
• Calcium carbonate tablets
• References
• Further Reading
• The Boron Group – Group
• General chemistry of group elements
• Extraction
• Chemical properties
• Boron
• Introduction
• Pharmaceutical applications of boric acid
• Bortezomib
• Aluminium
• Introduction
• Biological importance
• Al + and its use in water purification
• Aluminium-based adjuvants
• Antacids
• Aluminium-based therapeutics – alginate raft formulations
• Phosphate binders
• Antiperspirant
• Potential aluminium toxicity
• Gallium
• Introduction
• Chemistry
• Pharmacology of gallium-based drugs
• Gallium nitrate – multivalent use
• Gallium -quinolinolate
• Gallium maltolate
• Toxicity and administration
• Exercises
• Case studies
• Boric acid – API analysis
• Aluminium hydroxide tablets
• References
• Further Reading
• The Carbon Group
• General chemistry of group elements
• Occurrence, extraction and use of group elements
• Oxidation states and ionisation energies
• Typical compounds of group elements
• Silicon-based drugs versus carbon-based analogues
• Introduction of silicon groups
• Silicon isosters
• Organosilicon drugs
• Organogermanium compounds: balancing act between an anticancer drug and a herbal
• supplement
• Germanium sesquioxide
• Spirogermanium
• Exercises
• Cases studies
• Simethicone
• Germanium supplements
• References
• Further Reading
• Group Elements
• Chemistry of group elements
• Occurrence and extraction
• Physical properties
• Oxidation states and ionisation energy
• Chemical properties
• Phosphorus
• Adenosine phosphates: ATP, ADP and AMP
• Phosphate in DNA
• Clinical use of phosphate
• Drug interactions and toxicity
• Arsenic
• Salvarsan: the magic bullet – the start of chemotherapy
• Arsenic trioxide: a modern anticancer drug?
• Exercises
• Case studies
• Phosphate solution for rectal use
• Forensic test for arsenic
• References
• Further Reading
• Transition Metals and d-Block Metal Chemistry
• What are d-block metals?
• Electronic configurations
• Characteristic properties
• Coordination numbers and geometries
• Crystal field theory
• Group : platinum anticancer agents
• Cisplatin
• Platinum anticancer agents
• Iron and ruthenium
• Iron
• Ruthenium
• The coinage metals
• General chemistry
• Copper-containing drugs
• Silver: the future of antimicrobial agents?
• Gold: the fight against rheumatoid arthritis
• Group elements: zinc and its role in biological systems
• General chemistry
• The role of zinc in biological systems
• Zinc: clinical applications and toxicity
• Exercises
• Case studies
• Silver nitrate solution
• Ferrous sulfate tablets
• Zinc sulfate eye drops
• References
• Further Reading
• Organometallic Chemistry
• What is organometallic chemistry?
• What are metallocenes?
• Ferrocene
• Ferrocene and its derivatives as biosensors
• Ferrocene derivatives as potential antimalarial agent
• Ferrocifen – a new promising agent against breast cancer?
• Titanocenes
• History of titanium-based anticancer agents: titanocene dichloride and budotitane
• Further developments of titanocenes as potential anticancer agents
• Vanadocenes
• Vanadocene dichloride as anticancer agents
• Further vanadium-based drugs: insulin mimetics
• Exercises
• Case study – titanium dioxide
• References
• Further Reading
• The Clinical Use of Lanthanoids
• Biology and toxicology of lanthanoids
• The clinical use of lanthanum carbonate
• The clinical application of cerium salts
• The use of gadolinium salts as MRI contrast agents
• Exercises
• Case study: lanthanum carbonate tablets
• References
• Further Reading
• Radioactive Compounds and Their Clinical Application
• What is radioactivity?
• The atomic structure
• Radioactive processes
• Radioactive decay
• Penetration potential
• Quantification of radioactivity
• Radiopharmacy: dispensing and protection
• Therapeutic use of radiopharmaceuticals
• Iodine: therapy for hyperthyroidism
• Strontium
• Boron neutron capture therapy (BNCT)
• Radiopharmaceuticals for imaging
• Technetium
• Fluoride: PET scan
• Gallium: PET
• Thallium
• Exercises
• Case studies
• A sample containing mTc was found to have a radioactivity of mCi at a m
• when the sample was tested
• A typical intravenous dose of mTc-albumin used for lung imaging contains a
• radioactivity of mCi
• Develop a quick-reference radioactive decay chart for I
• References
• Further Reading
• Chelation Therapy
• What is heavy-metal poisoning?
• What is chelation?
• Chelation therapy
• Calcium disodium edetate
• Dimercaprol (BAL)
• Dimercaptosuccinic acid (DMSA)
• Dimercapto- -propanesulfonic acid (DMPS)
• Lipoic acid (ALA)
• Exercises
• Case studies
• Disodium edetate
• Dimercaprol
• References
• Further Reading