Essentials of Inorganic Chemistry by Katja A. Strohfeldt – Medicinal inorganic chemistry, Why use metal-based drugs?, Basic inorganic principles, Electronic structures of atoms, Bonds, Exercises
Contents of Essentials of Inorganic Chemistry
- About the Companion Website
- Introduction
- Medicinal inorganic chemistry
- Why use metal-based drugs?
- Basic inorganic principles
- Electronic structures of atoms
- Bonds
- Exercises
- References
- Further Reading
- Alkali Metals
- Alkali metal ions
- Extraction of alkali metals: an introduction to redox chemistry
- Excursus: reduction – oxidation reactions
- Chemical behaviour of alkali metals
- Advantages and disadvantages using lithium-based drugs
- Isotopes of lithium and their medicinal application
- Historical developments in lithium-based drugs
- The biology of lithium and its medicinal application
- Excursus: diagonal relationship and periodicity
- What are the pharmacological targets of lithium?
- Adverse effects and toxicity
- Sodium: an essential ion in the human body
- Osmosis
- Active transport of sodium ions
- Drugs, diet and toxicity
- Potassium and its clinical application
- Biological importance of potassium ions in the human body – action potential
- Excursus: the Nernst equation
- Potassium salts and their clinical application: hypokalaemia
- Adverse effects and toxicity: hyperkalaemia
- Exercises
- Case studies
- Lithium carbonate (Li CO ) tablets
- Sodium chloride eye drops
- References
- Further Reading
- Alkaline Earth Metals
- Earth alkaline metal ions
- Major uses and extraction
- Chemical properties
- Beryllium and chronic beryllium disease
- Magnesium: competition to lithium?
- Biological importance
- Clinical applications and preparations
- Calcium: the key to many human functions
- Biological importance
- How does dietary calcium intake influence our lives?
- Calcium deficiency: osteoporosis, hypertension and weight management
- Renal osteodystrophy
- Kidney stones
- Clinical application
- Side effects
- Barium: rat poison or radio-contrast agent?
- Exercises
- Case studies
- Magnesium hydroxide suspension
- Calcium carbonate tablets
- References
- Further Reading
- The Boron Group – Group
- General chemistry of group elements
- Extraction
- Chemical properties
- Boron
- Introduction
- Pharmaceutical applications of boric acid
- Bortezomib
- Aluminium
- Introduction
- Biological importance
- Al + and its use in water purification
- Aluminium-based adjuvants
- Antacids
- Aluminium-based therapeutics – alginate raft formulations
- Phosphate binders
- Antiperspirant
- Potential aluminium toxicity
- Gallium
- Introduction
- Chemistry
- Pharmacology of gallium-based drugs
- Gallium nitrate – multivalent use
- Gallium -quinolinolate
- Gallium maltolate
- Toxicity and administration
- Exercises
- Case studies
- Boric acid – API analysis
- Aluminium hydroxide tablets
- References
- Further Reading
- The Carbon Group
- General chemistry of group elements
- Occurrence, extraction and use of group elements
- Oxidation states and ionisation energies
- Typical compounds of group elements
- Silicon-based drugs versus carbon-based analogues
- Introduction of silicon groups
- Silicon isosters
- Organosilicon drugs
- Organogermanium compounds: balancing act between an anticancer drug and a herbal
- supplement
- Germanium sesquioxide
- Spirogermanium
- Exercises
- Cases studies
- Simethicone
- Germanium supplements
- References
- Further Reading
- Group Elements
- Chemistry of group elements
- Occurrence and extraction
- Physical properties
- Oxidation states and ionisation energy
- Chemical properties
- Phosphorus
- Adenosine phosphates: ATP, ADP and AMP
- Phosphate in DNA
- Clinical use of phosphate
- Drug interactions and toxicity
- Arsenic
- Salvarsan: the magic bullet – the start of chemotherapy
- Arsenic trioxide: a modern anticancer drug?
- Exercises
- Case studies
- Phosphate solution for rectal use
- Forensic test for arsenic
- References
- Further Reading
- Transition Metals and d-Block Metal Chemistry
- What are d-block metals?
- Electronic configurations
- Characteristic properties
- Coordination numbers and geometries
- Crystal field theory
- Group : platinum anticancer agents
- Cisplatin
- Platinum anticancer agents
- Iron and ruthenium
- Iron
- Ruthenium
- The coinage metals
- General chemistry
- Copper-containing drugs
- Silver: the future of antimicrobial agents?
- Gold: the fight against rheumatoid arthritis
- Group elements: zinc and its role in biological systems
- General chemistry
- The role of zinc in biological systems
- Zinc: clinical applications and toxicity
- Exercises
- Case studies
- Silver nitrate solution
- Ferrous sulfate tablets
- Zinc sulfate eye drops
- References
- Further Reading
- Organometallic Chemistry
- What is organometallic chemistry?
- What are metallocenes?
- Ferrocene
- Ferrocene and its derivatives as biosensors
- Ferrocene derivatives as potential antimalarial agent
- Ferrocifen – a new promising agent against breast cancer?
- Titanocenes
- History of titanium-based anticancer agents: titanocene dichloride and budotitane
- Further developments of titanocenes as potential anticancer agents
- Vanadocenes
- Vanadocene dichloride as anticancer agents
- Further vanadium-based drugs: insulin mimetics
- Exercises
- Case study – titanium dioxide
- References
- Further Reading
- The Clinical Use of Lanthanoids
- Biology and toxicology of lanthanoids
- The clinical use of lanthanum carbonate
- The clinical application of cerium salts
- The use of gadolinium salts as MRI contrast agents
- Exercises
- Case study: lanthanum carbonate tablets
- References
- Further Reading
- Radioactive Compounds and Their Clinical Application
- What is radioactivity?
- The atomic structure
- Radioactive processes
- Radioactive decay
- Penetration potential
- Quantification of radioactivity
- Radiopharmacy: dispensing and protection
- Therapeutic use of radiopharmaceuticals
- Iodine: therapy for hyperthyroidism
- Strontium
- Boron neutron capture therapy (BNCT)
- Radiopharmaceuticals for imaging
- Technetium
- Fluoride: PET scan
- Gallium: PET
- Thallium
- Exercises
- Case studies
- A sample containing mTc was found to have a radioactivity of mCi at a m
- when the sample was tested
- A typical intravenous dose of mTc-albumin used for lung imaging contains a
- radioactivity of mCi
- Develop a quick-reference radioactive decay chart for I
- References
- Further Reading
- Chelation Therapy
- What is heavy-metal poisoning?
- What is chelation?
- Chelation therapy
- Calcium disodium edetate
- Dimercaprol (BAL)
- Dimercaptosuccinic acid (DMSA)
- Dimercapto- -propanesulfonic acid (DMPS)
- Lipoic acid (ALA)
- Exercises
- Case studies
- Disodium edetate
- Dimercaprol
- References
- Further Reading
